Resistant and Refractory Hypertension: Antihypertensive Treatment Resistance vs Treatment Failure

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Refractory and Resistant Hypertension: Antihypertensive Treatment Failure versus Treatment Resistance

Resistant hypertension has for many decades been defined as difficult-to-treat hypertension in order to identify patients who may benefit from special diagnostic and/or therapeutic considerations. Recently, the term "refractory hypertension" has been proposed as a novel phenotype of antihypertensive failure, that is, patients whose blood pressure cannot be controlled with maximal treatment. Ear...

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Refractory Hypertension: Evidence of Heightened Sympathetic Activity as a Cause of Antihypertensive Treatment Failure.

Refractory hypertension is an extreme phenotype of treatment failure defined as uncontrolled blood pressure in spite of ≥5 classes of antihypertensive agents, including chlorthalidone and a mineralocorticoid receptor antagonist. A prospective evaluation of possible mechanisms of refractory hypertension has not been done. The goal of this study was to test for evidence of heightened sympathetic ...

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Hypertension, Antihypertensive Treatment, and Sudden Coronary Death

During 30 years of follow-up, there were 183 sadden deaths hi men and 77 hi women ages 35 to 94 years who participated hi the Framingham Study. Risk of sudden death was increased threefold in hypertensive persons but only if there was no previously diagnosed coronary heart disease. Men receiving antihypertensive treatment had more than twice the risk of sudden death compared with those who were...

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ژورنال

عنوان ژورنال: Canadian Journal of Cardiology

سال: 2016

ISSN: 0828-282X

DOI: 10.1016/j.cjca.2015.06.033